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KMID : 0043320130360060694
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Archives of Pharmacal Research
2013 Volume.36 No. 6 p.694 ~ p.701
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Site-selective reactions of hydrazonoyl chlorides with cyanoacetic hydrazide and its N-arylidene derivatives and anti-aggressive activity of prepared products
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Shawali Ahmad Sami
Farghaly Thoraya A.
Hussein Shadia M.
Abdalla Mohamed M.
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Abstract
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Reactions of hydrazonoyl halides with cyanoacetic hydrazide and its N-arylidene derivatives proceeded site-selectively and afforded the respective pyrazolo[3,4-d]pyridazine and aldehyde N-(1-aryl-3-acetyl-4-cyanopyrazol-5-yl)hydrazone derivatives. The structures of the products were elucidated on the basis of their spectral and elemental analyses. The anti-aggressive activity of the compounds prepared was screened.
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KEYWORD
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Site-selectivity, Hydrazonoyl halides, Pyrazoles, Pyrazolo[3, 4-d] pyridazines, Anti-aggressive activity
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